Description

3-Hydroxy-3-Methyl-5-Phosphonooxy-Pentanoic Acid is a high-purity biochemical intermediate of significant interest in advanced synthesis and research. This compound matters for its role as a key building block in the development of novel pharmaceuticals and bioactive molecules, particularly those targeting metabolic pathways. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for the synthesis of complex active pharmaceutical ingredients (APIs) and specialized reagents.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly statin analogs and other compounds targeting HMG-CoA reductase and related metabolic enzymes.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate metabolic pathways involving mevalonate and isoprenoid biosynthesis.
• Fine Chemical Synthesis: Serves as a specialized building block for constructing complex molecular architectures with phosphonate and carboxylic acid functionalities in custom synthesis projects.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation in pharmaceutical analysis.

Basic Information

Item	Details
Product Name	3-Hydroxy-3-Methyl-5-Phosphonooxy-Pentanoic Acid
CAS No.	73566-35-5
Molecular Formula	C6H13O8P
Molecular Weight	244.14 g/mol
Synonyms	5-Phosphonooxy-3-hydroxy-3-methylpentanoic acid; 3-Hydroxy-3-methyl-5-(phosphonooxy)pentanoic acid; HMPP Acid; 3-Hydroxy-3-methylglutaryl phosphate analog; Mevalonate-5-phosphate analog; (3-Hydroxy-3-methyl-5-phosphonooxy)valeric acid
EINECS	Contact for details

Quality Control

Our 3-Hydroxy-3-Methyl-5-Phosphonooxy-Pentanoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the stringent requirements for research and development use. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.