Description

3-Bromo-5-(tert-Butyl)-2-Methoxybenzoic Acid is a high-purity, synthetically valuable benzoic acid derivative characterized by its bromine and tert-butyl substituents. This compound serves as a crucial advanced pharmaceutical intermediate and a versatile building block in organic synthesis for the development of complex molecules. It is primarily needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific steric and electronic properties into their target compounds.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders or inflammatory diseases.
• Agrochemical Synthesis: Used in the research and development of novel herbicides and fungicides, where the tert-butyl group can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in metal-catalyzed cross-coupling reactions, such as Suzuki or Buchwald-Hartwig amination.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, or metal-organic frameworks (MOFs) due to its rigid, substituted aromatic core.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.
• Academic Research: Utilized in university and institutional labs for methodological studies in organic chemistry, including studies on directed ortho-metalation and functional group transformations.

Basic Information

Product Name	3-Bromo-5-(tert-Butyl)-2-Methoxybenzoic Acid
CAS No.	73469-59-7
Molecular Formula	C₁₂H₁₅BrO₃
Molecular Weight	287.15 g/mol
Synonyms	3-Bromo-5-tert-butyl-2-methoxybenzoic acid; 2-Methoxy-3-bromo-5-tert-butylbenzoic acid; Benzoic acid, 3-bromo-5-(1,1-dimethylethyl)-2-methoxy-; 5-(tert-Butyl)-3-bromo-2-methoxybenzoic acid; 3-Bromo-5-(tert-butyl)-2-anisic acid; 2-Methoxy-3-bromo-5-(1,1-dimethylethyl)benzoic acid; 3-Bromo-5-(1,1-dimethylethyl)-2-methoxybenzoic acid
EINECS	Contact for details

Quality Control

Our 3-Bromo-5-(tert-Butyl)-2-Methoxybenzoic Acid is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed when not in use to prevent absorption of atmospheric moisture. Store away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.