Description

Milbemycin B, 5-o-Demethyl-28-Deoxy-5-o-[(1,1-Dimethylethyl)Dimethylsilyl]-6,28-Epoxy-13-Hydroxy-25-(1-Methylpropyl)-, [6R,13S,25R(S)]- is a key semi-synthetic intermediate in the production of potent macrocyclic lactone anthelmintics and acaricides. This compound is critical for researchers and manufacturers developing next-generation parasitic control agents for veterinary and agricultural applications. It is primarily utilized by the pharmaceutical and agrochemical industries for the synthesis of advanced milbemycin and avermectin derivatives.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of potent anthelmintic drugs used in veterinary medicine.
• Agrochemical Research: Serves as a key precursor in developing novel, high-efficacy acaricides and insecticides for crop protection.
• API Synthesis: Used in the manufacturing process of active pharmaceutical ingredients (APIs) belonging to the macrocyclic lactone class.
• Biochemical Research: A valuable reference standard and tool compound for studying glutamate-gated chloride channel modulation.
• Veterinary Product Development: Integral to creating formulations for parasite control in livestock and companion animals.

Basic Information

Product Name	Milbemycin B, 5-o-Demethyl-28-Deoxy-5-o-[(1,1-Dimethylethyl)Dimethylsilyl]-6,28-Epoxy-13-Hydroxy-25-(1-Methylpropyl)-, [6R,13S,25R(S)]-
CAS No.	73162-96-6
Molecular Formula	C₄₃H₇₂O₇Si
Molecular Weight	729.1 g/mol
Synonyms	5-O-Demethyl-28-deoxy-5-O-[(1,1-dimethylethyl)dimethylsilyl]-6,28-epoxy-13-hydroxy-25-(1-methylpropyl)milbemycin B; 5-O-(tert-Butyldimethylsilyl)-5-O-demethyl-28-deoxy-6,28-epoxy-13-hydroxy-25-(1-methylpropyl)milbemycin B; Milbemycin B TBDMS Ether; 5-O-TBDMS-Milbemycin B; (6R,13S,25R(S))-5-O-Demethyl-28-deoxy-5-O-[(1,1-dimethylethyl)dimethylsilyl]-6,28-epoxy-13-hydroxy-25-(1-methylpropyl)milbemycin B
EINECS	Contact for details

Quality Control

Our Milbemycin B intermediate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting your regulatory and R&D needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere when not in use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.