Description

1-(2,4,6-Triisopropylbenzenesulfonyl)-3-Nitro-1H-1,2,4-Triazole is a specialized sulfonylation reagent and a key synthetic intermediate in advanced organic chemistry. Its primary value lies in its role as a highly effective activating agent for nucleophilic substitution reactions, particularly in the synthesis of complex heterocyclic compounds and active pharmaceutical ingredients (APIs). This compound is essential for researchers and process chemists in pharmaceutical development, agrochemical research, and materials science who require precise and efficient methods for constructing challenging molecular architectures.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, particularly those containing triazole or other nitrogen-rich heterocycles.
• Agrochemical Synthesis: Used in the development of advanced pesticides, herbicides, and fungicides where the triazole moiety imparts biological activity.
• Peptide Chemistry: Serves as a coupling reagent or protecting group agent in the synthesis of peptides and modified amino acids.
• Nucleoside & Nucleotide Chemistry: Employed in the modification and functionalization of nucleosides for antiviral or anticancer research.
• Polymer Science: Acts as a monomer or cross-linking agent in the production of specialty polymers with unique thermal or chemical properties.
• Material Science Research: Utilized in the creation of organic electronic materials, such as charge-transport layers or light-emitting components.
• Chemical Biology Probes: Facilitates the labeling or modification of biomolecules for diagnostic and research applications.
• General Laboratory Reagent: Used as a specialized sulfonylating agent in multistep organic synthesis for academic and industrial R&D.

Basic Information

Product Name	1-(2,4,6-Triisopropylbenzenesulfonyl)-3-Nitro-1H-1,2,4-Triazole
CAS No.	73118-37-3
Molecular Formula	C17H25N4O4S
Molecular Weight	381.47 g/mol
Synonyms	3-Nitro-1-(2,4,6-triisopropylbenzenesulfonyl)-1H-1,2,4-triazole; 1,2,4-Triazole, 1-[(2,4,6-triisopropylphenyl)sulfonyl]-3-nitro-; TIPSNT; Triisopropylbenzenesulfonyl Nitrotriazole; Trisyl Nitrotriazole; 1H-1,2,4-Triazole, 1-[(2,4,6-triisopropylphenyl)sulfonyl]-3-nitro-; Nitrotriazole Trisylating Agent
EINECS	Contact for details

Quality Control

Our 1-(2,4,6-Triisopropylbenzenesulfonyl)-3-Nitro-1H-1,2,4-Triazole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or production specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere such as nitrogen or argon to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.