Description

n-Acetyl-Glutamylsulfamethoxazole is a chemically modified derivative of the antibiotic sulfamethoxazole, designed for enhanced pharmacological properties and targeted delivery. This compound is significant for its potential role in advanced pharmaceutical research and development, particularly in creating prodrugs with improved bioavailability and reduced side effects. It is primarily needed by research institutions, pharmaceutical manufacturers, and fine chemical suppliers focused on developing next-generation antibacterial agents and novel therapeutic conjugates.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel prodrugs and targeted antibiotic conjugates.
• Antibacterial Research: Used in preclinical studies to investigate new mechanisms of action and combat antibiotic resistance.
• Bioconjugation Studies: Employed in the development of drug-antibody or drug-peptide conjugates for targeted therapy.
• Metabolism and Pharmacokinetics (PK/PD) Studies: Acts as a model compound to study drug release profiles and metabolic pathways.
• Analytical Reference Standard: Provides a high-purity standard for quality control and analytical method development in pharmaceutical labs.
• Academic and Institutional Research: Supports chemical biology and medicinal chemistry programs in universities and research institutes.

Basic Information

Product Name	n-Acetyl-Glutamylsulfamethoxazole
CAS No.	72756-69-5
Molecular Formula	C18H22N4O7S
Molecular Weight	438.46 g/mol
Synonyms	N-Acetyl-L-glutamylsulfamethoxazole; N-Acetylglutamylsulfamethoxazole; Acetylglutamylsulfamethoxazole; Sulfamethoxazole N-acetylglutamate conjugate; 4-Amino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide, N-acetyl-L-glutamyl derivative; AG-SMX; NAG-SMX; SMX-Glu(Ac)
EINECS	Contact for details

Quality Control

Our n-Acetyl-Glutamylsulfamethoxazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets high-grade standards suitable for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.