Description

1-(Benzyloxycarbonyl)Pyrrolidine-2-Carboxylic Acid is a key N-protected amino acid derivative, serving as a crucial building block in advanced organic synthesis. Its primary value lies in providing a protected pyrrolidine scaffold for the controlled construction of complex molecules, particularly peptides and peptidomimetics. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A vital precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing proline or pyrrolidine motifs.
• Peptide Synthesis: Used as a protected amino acid (Cbz-Pro-OH) in solid-phase and solution-phase peptide synthesis to introduce proline residues.
• Protease Inhibitor Development: Serves as a core scaffold for designing inhibitors targeting enzymes like dipeptidyl peptidase-4 (DPP-4).
• Chemical Biology & Research: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Fine Chemical Synthesis: A versatile chiral building block for synthesizing complex natural products and specialty chemicals.

Basic Information

Product Name	1-(Benzyloxycarbonyl)Pyrrolidine-2-Carboxylic Acid
CAS No.	72580-07-5
Molecular Formula	C13H15NO4
Molecular Weight	249.26 g/mol
Synonyms	N-Carbobenzoxy-L-proline; Cbz-L-Proline; N-Cbz-L-Proline; (S)-1-((Benzyloxy)carbonyl)pyrrolidine-2-carboxylic acid; L-Proline, N-[(phenylmethoxy)carbonyl]-; Z-L-Proline; Z-Pro-OH; N-[(Benzyloxy)carbonyl]-L-proline
EINECS	Contact for details

Quality Control

Our 1-(Benzyloxycarbonyl)Pyrrolidine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.