Description

5-o-Benzyl-D-Ribose is a protected sugar derivative, specifically a benzyl-protected form of D-ribose, serving as a crucial chiral building block in organic synthesis. Its primary value lies in enabling the controlled synthesis of complex nucleoside analogs and other bioactive molecules where the ribose moiety is essential. This high-purity intermediate is critically needed by pharmaceutical R&D laboratories and fine chemical manufacturers developing antiviral drugs, mRNA therapeutics, and novel nucleotide-based active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key starting material for the synthesis of nucleoside reverse transcriptase inhibitors (NRTIs) and other antiviral agents.
• mRNA Vaccine & Therapeutic Development: Used in the research and production of modified nucleosides for stabilizing mRNA constructs.
• Oligonucleotide Synthesis: Serves as a protected precursor for incorporating ribose units into antisense oligonucleotides and siRNAs.
• Glycochemistry & Glycobiology Research: Employed in the synthesis of complex carbohydrates, glycoconjugates, and glycomimetics.
• Process Chemistry & Scale-up: Utilized in the development and commercial-scale manufacturing routes for nucleotide-based APIs.
• Chemical Biology Probes: Acts as a building block for creating labeled nucleotides or metabolic probes for cellular studies.

Basic Information

Product Name	5-o-Benzyl-D-Ribose
CAS No.	72369-89-2
Molecular Formula	C₁₂H₁₆O₅
Molecular Weight	240.25 g/mol
Synonyms	D-Ribose, 5-O-benzyl-; 5-O-Benzyl-D-ribofuranose; 5-O-Benzyl-ribose; 1,2-O-Isopropylidene-5-O-benzyl-D-ribofuranose (common protected form); 5-O-Benzyl-1,2-O-isopropylidene-α-D-ribofuranose; Benzyl D-riboside (derivative); 5-Benzyloxy-D-ribose
EINECS	Contact for details

Quality Control

Our 5-o-Benzyl-D-Ribose is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, typically meeting standards suitable for pharmaceutical R&D. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support customer audits and can provide material to meet specific pharmacopeial or internal quality specifications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]²⁰D	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.