Description

4-(Trifluoromethoxy)Phenoxyacetic Acid is a high-purity fluorinated organic acid building block with the CAS registry number 72220-50-9. This compound is valued for its unique trifluoromethoxy-substituted phenoxy moiety, which imparts enhanced metabolic stability and lipophilicity to target molecules. It is primarily sought by R&D and process development teams in the pharmaceutical and agrochemical industries for use as a key intermediate in the synthesis of advanced active ingredients.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the trifluoromethoxy group can improve biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, contributing to improved performance and stability.
• Advanced Polymer Modification: Employed to introduce fluorine-containing side chains into polymers, enhancing their chemical resistance, thermal stability, and surface properties.
• Chemical Research & Development: A versatile reagent for exploring new fluorination chemistry and creating specialized libraries of compounds for high-throughput screening.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and fine chemical manufacturers for use in custom synthesis projects requiring high-purity fluorinated intermediates.

Basic Information

Product Name	4-(Trifluoromethoxy)Phenoxyacetic Acid
CAS No.	72220-50-9
Molecular Formula	C9H7F3O4
Molecular Weight	236.15 g/mol
Synonyms	4-(Trifluoromethoxy)phenoxyacetic acid; 2-[4-(Trifluoromethoxy)phenoxy]acetic acid; Phenoxyacetic acid, 4-(trifluoromethoxy)-; NSC 406329; 72220-50-9; α-(4-Trifluoromethoxyphenoxy)acetic Acid; 4-(Trifluoromethoxy)phenoxyethanoic acid
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethoxy)Phenoxyacetic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals. We provide comprehensive Certificates of Analysis (COA) with each shipment, ensuring traceability and compliance with your internal specifications and regulatory requirements for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and oxidizing agents. Recommended storage temperature is between 15°C and 25°C. The product is compatible with strong acid/organic solvent environments but should be handled with standard laboratory precautions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.