Description

3H-Spiro[1-Benzofuran-2,4''-Piperidine] is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic structure. This compound is of significant commercial importance for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs). It is primarily required by research institutions and manufacturers in the pharmaceutical and agrochemical industries for developing new therapeutic and crop protection agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel central nervous system (CNS) active drugs and other therapeutic molecules.
• Agrochemical Research: Used as a core scaffold for developing new-generation pesticides and herbicides with specific modes of action.
• Organic Synthesis Building Block: Employed in academic and industrial R&D for constructing complex spirocyclic and heterocyclic compounds.
• Medicinal Chemistry: Serves as a versatile template for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Chemical Reference Standard: Supplied as a high-purity standard for analytical method development and quality control in API manufacturing.

Basic Information

Product Name	3H-Spiro[1-Benzofuran-2,4''-Piperidine]
CAS No.	71916-73-9
Molecular Formula	C12H13NO
Molecular Weight	187.24 g/mol
Synonyms	3H-Spiro[2-benzofuran-1,4'-piperidine]; 3H-Spiro[benzofuran-2,4'-piperidine]; 1',3'-Dihydrospiro[piperidine-4,2'-benzofuran]; Spiro[benzofuran-2(3H),4'-piperidine]; 71916-73-9; 3H-Spiro(1-benzofuran-2,4'-piperidine)
EINECS	Contact for details

Quality Control

Our 3H-Spiro[1-Benzofuran-2,4''-Piperidine] is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.