Description

Ivermectin B1 Mono-Sugar Derivative is a key semi-synthetic intermediate derived from the fermentation product Avermectin B1. This compound is of critical importance in the synthesis of advanced antiparasitic agents, including Ivermectin itself, due to its modified sugar moiety which influences biological activity and pharmacokinetics. It is primarily required by manufacturers in the pharmaceutical and veterinary medicine sectors for the research, development, and production of next-generation endectocide formulations.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of Ivermectin and related macrocyclic lactone antiparasitics for human and veterinary use.
• Veterinary API Production: Used in the manufacturing of active pharmaceutical ingredients (APIs) for animal health products targeting internal and external parasites.
• Research & Development: Serves as a reference standard and starting material in medicinal chemistry research for novel anthelmintic and insecticidal compounds.
• Process Chemistry: Employed in scale-up and optimization studies for the commercial production of avermectin derivatives.
• Agrochemical Synthesis: Potential intermediate in the development of crop protection agents with insecticidal properties.

Basic Information

Product Name	Ivermectin B1 Mono-Sugar Derivative
CAS No.	71837-27-9
Molecular Formula	C₄₈H₇₂O₁₄
Molecular Weight	873.1 g/mol
Synonyms	5-O-Demethyl-22,23-dihydroavermectin B1 monosaccharide; 22,23-Dihydroavermectin B1a monosaccharide; Ivermectin B1a aglycone derivative; Avermectin B1 monosaccharide derivative; 5-O-Desmethyl-22,23-dihydroavermectin B1a; MK-0933 derivative; 4"-Deoxy-4"-epi-acetylamino-avermectin B1
EINECS	Contact for details

Quality Control

Our Ivermectin B1 Mono-Sugar Derivative is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical intermediate applications. Certificates of Analysis (COA) documenting purity, related substances, and residual solvents are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.