Description

8-Fluoroquinolin-2(1H)-One is a high-purity fluorinated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters as a versatile precursor for developing novel pharmaceuticals and agrochemicals, where the fluorine atom and quinolinone core are key structural motifs for modulating biological activity and physicochemical properties. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of fluorinated quinolone and quinazolinone-based drug candidates, including potential antibiotics and kinase inhibitors.
• Agrochemical Synthesis: Used in constructing advanced active ingredients for crop protection, where the fluorine atom enhances stability, bioavailability, and activity.
• Material Science Research: Serves as a building block for organic electronic materials, ligands for catalysis, and fluorescent probes due to its conjugated heterocyclic structure.
• Chemical Biology: Employed in the design and synthesis of molecular probes and tool compounds for studying biological targets and pathways.
• Academic & Contract Research: Utilized in university and CRO laboratories for methodological studies in fluorination chemistry and heterocycle functionalization.

Basic Information

Product Name	8-Fluoroquinolin-2(1H)-One
CAS No.	71738-83-5
Molecular Formula	C9H6FNO
Molecular Weight	163.15 g/mol
Synonyms	8-Fluoro-2-hydroxyquinoline; 8-Fluoro-2-quinolinol; 8-Fluoro-2(1H)-quinolinone; 2-Hydroxy-8-fluoroquinoline; 8-Fluoro-1H-quinolin-2-one; 8-Fluoroquinolin-2-ol
EINECS	Contact for details

Quality Control

Our 8-Fluoroquinolin-2(1H)-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific project requirements. We are committed to supplying material that meets the high standards required for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). The compound should be kept under an inert atmosphere for long-term storage to ensure stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.