Description

2-Chloro-5-(Difluoromethyl)Pyridine is a versatile and high-value halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring both chloro and difluoromethyl substituents, makes it an essential intermediate for creating compounds with tailored biological activity and material properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in antiviral and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the manufacture of advanced pesticides, herbicides, and fungicides, where the difluoromethyl group can enhance metabolic stability and bioavailability.
• Material Science Research: Serves as a precursor for synthesizing specialized ligands, functionalized polymers, and liquid crystal materials.
• Chemical Research & Development: A valuable reagent in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic substitution reactions to construct complex heterocyclic systems.

Basic Information

Product Name	2-Chloro-5-(Difluoromethyl)Pyridine
CAS No.	71701-99-0
Molecular Formula	C6H4ClF2N
Molecular Weight	163.55 g/mol
Synonyms	2-Chloro-5-(difluoromethyl)pyridine; 5-(Difluoromethyl)-2-chloropyridine; 2-Chloro-5-difluoromethylpyridine; Pyridine, 2-chloro-5-(difluoromethyl)-; 71701-99-0; 2-Chloro-5-(difluoromethyl)pyridine (CAS 71701-99-0)
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-5-(Difluoromethyl)Pyridine is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) including purity (HPLC/GC), identity confirmation (IR, NMR), and impurity profile is available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.