Description

6-(Trifluoromethyl)Quinoline-3-Carboxylic Acid is a high-value, multifunctional heterocyclic building block prized for its unique structural and electronic properties. This compound is essential for the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where the trifluoromethyl and carboxylic acid groups offer critical points for derivatization and modulation of biological activity. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with enhanced efficacy and stability.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-infectives, and oncology therapeutics.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the quinoline scaffold and fluorine atoms contribute to improved pest resistance and environmental profile.
• Material Science Research: Serves as a building block for organic light-emitting diodes (OLEDs), liquid crystals, and other electronic materials due to its electron-deficient quinoline core.
• Coordination Chemistry & Ligand Design: The carboxylic acid functionality allows it to act as a chelating ligand for metal ions, useful in catalysis and sensor development.
• Chemical Biology & Proteomics: Employed in the design of molecular probes and activity-based protein profiling (ABPP) agents to study enzyme function.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring complex, fluorinated heterocyclic architectures.

Basic Information

Product Name	6-(Trifluoromethyl)Quinoline-3-Carboxylic Acid
CAS No.	71082-45-6
Molecular Formula	C11H6F3NO2
Molecular Weight	241.17 g/mol
Synonyms	3-Quinolinecarboxylic acid, 6-(trifluoromethyl)-; 6-(Trifluoromethyl)-3-quinolinecarboxylic acid; 6-Trifluoromethylquinoline-3-carboxylic acid; Quinoline-3-carboxylic acid, 6-(trifluoromethyl)-; 6-Trifluoromethyl-3-quinolinecarboxylic acid; 6-CF3-Quinoline-3-carboxylic acid; 6-(Trifluoromethyl)quinoline-3-carboxylate
EINECS	Contact for details

Quality Control

Every batch of 6-(Trifluoromethyl)Quinoline-3-Carboxylic Acid is manufactured under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency that meet the stringent requirements of research and cGMP-grade synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment to guarantee full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.