Description

(2S)-(+)-Glycidyl Tosylate is a high-value, enantiomerically pure chiral building block and electrophilic glycidating agent. Its core value proposition lies in its ability to introduce a protected glycidol moiety with defined stereochemistry into target molecules, enabling the synthesis of complex, optically active intermediates. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced material sectors who require precise stereochemical control in their synthetic routes.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly β-blockers, antiviral agents, and other therapeutics where stereochemistry is critical.
• Agrochemical Synthesis: Used in the production of enantiomerically pure herbicides, fungicides, and plant growth regulators to enhance efficacy and reduce environmental impact.
• Asymmetric Synthesis: Serves as a versatile electrophile in nucleophilic ring-opening reactions to produce chiral 1,2-diols, amino alcohols, and other functionalized compounds.
• Liquid Crystal & Polymer Chemistry: A precursor for chiral dopants and monomers used in the manufacture of advanced optical materials and polymers with specific helical structures.
• Chemical Biology & Proteomics: Useful as an affinity label or linker for modifying proteins and other biomolecules due to its reactive epoxide group.
• Catalyst & Ligand Development: Employed in the preparation of chiral ligands and organocatalysts for asymmetric transformations.

Basic Information

Product Name	(2S)-(+)-Glycidyl Tosylate
CAS No.	70987-78-9
Molecular Formula	C10H12O4S
Molecular Weight	228.26 g/mol
Synonyms	(S)-(+)-Glycidyl 4-Methylbenzenesulfonate; (2S)-(-)-2,3-Epoxypropyl p-Toluenesulfonate; (S)-Glycidyl Tosylate; (S)-(+)-Epoxypropyl Tosylate; (S)-(-)-Glycidyl p-Toluenesulfonate; (2S)-Oxiran-2-ylmethyl 4-methylbenzenesulfonate; (S)-Epibromohydrin p-Toluenesulfonate (related); L-Glycidyl Tosylate
EINECS	Contact for details

Quality Control

Our (2S)-(+)-Glycidyl Tosylate is produced under strict quality management systems. Every batch undergoes comprehensive analytical testing to ensure high chemical and enantiomeric purity, meeting the stringent requirements for chiral intermediates. Specifications are verified by techniques including HPLC, GC, and polarimetry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and specific rotation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Specific Rotation [α]20/D	+10.0° to +12.0° (c=1 in CHCl3)
Melting Point	65 - 68 °C
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.