Description

2-(4-Methoxybenzyl)-2H-Tetrazole-5-Carboxylic Acid is a high-purity, versatile heterocyclic building block of significant importance in modern synthetic chemistry. Its core value lies in its role as a key intermediate for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and advanced materials. This compound is essential for research and production teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce the tetrazole pharmacophore or carboxylic acid functionality into their target structures.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of sartans (Angiotensin II Receptor Blockers) and other drug candidates containing the tetrazole moiety.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides where the tetrazole ring enhances biological activity.
• Coordination Chemistry & Ligand Design: Serves as a precursor for designing polydentate ligands in catalysis and material science applications.
• Peptidomimetics & Bioisosteres: Employed to replace carboxylic acid groups in peptide analogs, improving metabolic stability and binding affinity.
• Polymer Chemistry: Acts as a monomer or cross-linking agent for creating functional polymers with specific thermal or chemical properties.
• Research & Development: A valuable reagent for medicinal chemistry and organic synthesis research in academic and industrial laboratories.

Basic Information

Product Name	2-(4-Methoxybenzyl)-2H-Tetrazole-5-Carboxylic Acid
CAS No.	70978-20-0
Molecular Formula	C10H10N4O3
Molecular Weight	234.21 g/mol
Synonyms	5-Carboxy-2-(4-methoxybenzyl)-2H-tetrazole; 2-(4-Methoxybenzyl)-1H-tetrazole-5-carboxylic acid; 2H-Tetrazole-5-carboxylic acid, 2-[(4-methoxyphenyl)methyl]-; 2-(p-Methoxybenzyl)-2H-tetrazole-5-carboxylic acid; 2-(4-Methoxybenzyl)-2H-tetrazole-5-carboxylic acid; 70978-20-0; 2-(4-Methoxybenzyl)-1,2,3,4-tetrazole-5-carboxylic acid
EINECS	Contact for details

Quality Control

Our 2-(4-Methoxybenzyl)-2H-Tetrazole-5-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP, ICH guidelines, and other relevant regulatory frameworks for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Purity (HPLC, Area %)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.