Description

D-[1-13C]Threose is a stable isotope-labeled derivative of the four-carbon sugar threose, specifically enriched with carbon-13 at the C-1 position. This compound is a critical tool for advanced metabolic and biochemical research, enabling precise tracing of carbohydrate pathways and structural analysis via Nuclear Magnetic Resonance (NMR) spectroscopy. It is essential for researchers and analytical laboratories in the pharmaceutical, biotechnology, and life science sectors who require high-purity, isotopically labeled standards for tracer studies, metabolic flux analysis, and complex biomolecular investigations.

Application

• Metabolic Tracer Studies: Used to trace and quantify metabolic pathways in biological systems, including glycolysis, pentose phosphate pathway, and nucleotide sugar metabolism.
• NMR Spectroscopy: Serves as an internal standard or labeled substrate for structural elucidation and dynamic studies of carbohydrates and glycoconjugates.
• Biochemical Research: A key reagent in enzymatic studies to investigate the mechanism and kinetics of aldolases, isomerases, and other sugar-metabolizing enzymes.
• Pharmaceutical Development: Employed in drug metabolism and pharmacokinetics (DMPK) studies to track the fate of sugar-based drug molecules or prodrugs.
• Glycobiology & Glycomics: Utilized in the synthesis of labeled glycans or as a probe to study glycosylation processes and carbohydrate-protein interactions.
• Diagnostic Agent Development: Potential use in the formulation of labeled compounds for advanced diagnostic imaging techniques like hyperpolarized MRI.

Basic Information

Product Name	D-[1-13C]Threose
CAS No.	70849-20-6
Molecular Formula	C413CH8O4
Molecular Weight	122.10 g/mol (for 13C1 isotopologue)
Synonyms	(2R,3S)-1,2,3,4-Tetrahydroxybutane-1-13C; D-Threose-1-13C; (2R,3S)-1,2,3,4-Tetrahydroxybutane-1-carbon-13C; D-13C1-Threose; 1-13C-D-Threose; Threose-1-13C; Isotopically labeled D-Threose
EINECS	Contact for details

Quality Control

Every batch of D-[1-13C]Threose is manufactured and analyzed under strict quality control protocols to ensure the highest isotopic and chemical purity for research applications. Our standard quality commitment includes comprehensive testing for identity, isotopic enrichment, chemical purity, and specific optical rotation. Certificates of Analysis (COA) detailing batch-specific results from NMR, HPLC, and mass spectrometry are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a cool, dry place. This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient humidity or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C
Specific Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.