Description

D-Erythrose-1-13C (As A Solution In Water) is a stable isotope-labeled analog of the four-carbon sugar, D-erythrose, specifically enriched with carbon-13 at the C-1 position and supplied as a convenient aqueous solution. This compound is a critical tool for advanced metabolic research and tracer studies, enabling precise tracking of biochemical pathways and flux analysis. It is primarily utilized by research scientists and process development specialists in the pharmaceutical, biotechnology, and life science sectors for applications in drug metabolism studies, enzymology, and carbohydrate chemistry.

Application

• Metabolic Pathway Tracing: As a 13C-labeled tracer for investigating the pentose phosphate pathway, glycan biosynthesis, and other carbohydrate metabolic networks in cell cultures and in vivo models.
• Drug Metabolism & Pharmacokinetics (DMPK): Used to synthesize isotopically labeled drug candidates or metabolites for mass spectrometry-based quantification and absorption, distribution, metabolism, and excretion (ADME) studies.
• Enzyme Mechanism Studies: Serves as a substrate for enzymes like transketolases and aldolases to elucidate reaction mechanisms and kinetics using NMR or LC-MS detection.
• Biomolecular NMR Spectroscopy: Provides a site-specific 13C label for structural and dynamic studies of proteins or complexes that bind carbohydrate motifs.
• Stable Isotope Probing (SIP): Employed in microbial ecology to track the assimilation of carbon sources by specific microorganisms in complex environmental samples.
• Chemical Synthesis Intermediate: Acts as a chiral building block for the synthesis of more complex, isotopically labeled sugars, nucleosides, or natural products.

Basic Information

Product Name	D-Erythrose-1-13C (As A Solution In Water)
CAS No.	70849-19-3
Molecular Formula	C413CH8O4 (in solution with H2O)
Molecular Weight	Contact for details
Synonyms	(2R,3R)-1,2,3,4-Tetrahydroxybutane-1-13C; D-(-)-Erythrose-1-13C; Erythrose-1-13C (D-form); 13C Labeled D-Erythrose; 1-13C-D-Erythrose; (2R,3R)-1,2,3,4-Tetrahydroxybutyl-1-13C Alcohol; D-Threose Isomer-1-13C
EINECS	Contact for details

Quality Control

Our D-Erythrose-1-13C solution is produced and controlled under strict quality management systems. Each batch is characterized to ensure high chemical and isotopic purity, with key parameters including assay, enantiomeric purity, and 13C enrichment level verified by techniques such as NMR and HPLC. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the aqueous solution at -20°C or below. Avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	Clear, colorless to slightly yellow aqueous solution
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95% (D-Erythrose-1-13C)
Isotopic Enrichment (13C)	≥ 99 atom %
Optical Purity (Chiral HPLC)	≥ 98% ee (D-enantiomer)
pH	Contact for details
Concentration	Customizable (e.g., 10-100 mg/mL in water)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.