Description

Ethyl 7-Chloro-1-Ethyl-6-Fluoro-1,4-Dihydro-4-Oxo-Quinoline-5-Carboxylate is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. Its core value lies in its role as a critical building block for the synthesis of modern fluoroquinolone antibiotics, enabling the development of potent antimicrobial agents. This compound is essential for research institutions, fine chemical manufacturers, and pharmaceutical companies engaged in the development and production of next-generation antibacterial therapeutics.

Application

• Key Intermediate for Fluoroquinolone Antibiotics: Serves as a crucial precursor in the synthesis of active pharmaceutical ingredients (APIs) such as Ciprofloxacin, Enrofloxacin, and related derivatives.
• Pharmaceutical Research & Development: Used in medicinal chemistry for the discovery and structural modification of new antibacterial compounds with improved efficacy and safety profiles.
• Fine Chemical Synthesis: Employed in multi-step organic synthesis to construct complex quinoline-based molecular frameworks.
• Veterinary Medicine Production: Integral to the manufacturing process of broad-spectrum antibiotics used in animal health.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for the scale-up and commercial production of antibiotic formulations.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and regulatory compliance testing in API manufacturing.

Basic Information

Item	Details
Product Name	Ethyl 7-Chloro-1-Ethyl-6-Fluoro-1,4-Dihydro-4-Oxo-Quinoline-5-Carboxylate
CAS No.	70458-94-5
Molecular Formula	C₁₄H₁₃ClFNO₃
Molecular Weight	297.71 g/mol
Synonyms	7-Chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-5-carboxylic acid ethyl ester; Ethyl 7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-5-carboxylate; 5-Carbethoxy-7-chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxoquinoline; CFCQ; Intermediate for Ciprofloxacin; 1-Ethyl-7-chloro-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid ethyl ester; Quinolone Carboxylate Ester Intermediate
EINECS	Contact for details

Quality Control

Our Ethyl 7-Chloro-1-Ethyl-6-Fluoro-1,4-Dihydro-4-Oxo-Quinoline-5-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR, to ensure it meets the stringent requirements for pharmaceutical intermediate applications. Certificates of Analysis (COA) documenting full specifications are provided with each shipment to guarantee traceability, consistency, and compliance with cGMP standards where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.