Description

Colominic Acid Sodium Salt is a high-purity, standardized polysialic acid derivative, a linear homopolymer of α-2,8-linked N-acetylneuraminic acid. This compound is a critical reagent and standard in glycobiology research and biopharmaceutical development due to its defined structure and biological relevance. It is essential for scientists and manufacturers in the fields of neuroscience, vaccine development, and advanced therapeutic research, where precise molecular interactions are paramount.

Application

• Biomedical Research Standard: Used as a reference standard for the quantification and characterization of polysialic acid in neural cell adhesion molecules (NCAM) and other glycoproteins.
• Vaccine Adjuvant & Carrier Development: Explored for its immunomodulatory properties and potential as a biocompatible carrier platform to enhance vaccine efficacy and targeted drug delivery.
• Neuroscience & Regeneration Studies: Applied in studies of neural development, plasticity, and repair, leveraging its role as a natural modulator of cell-cell interactions.
• Diagnostic Assay Development: Serves as a critical antigen or coating material in immunoassays and biosensors designed to detect polysialic acid-expressing cells, such as certain cancer cells.
• Enzymatic Substrate: Acts as a specific substrate for endoneuraminidases (sialidases) and other enzymes involved in sialic acid metabolism for kinetic and inhibition studies.
• Biomaterial & Surface Engineering: Utilized to modify surfaces to create bioactive, non-fouling, or neural-compatible interfaces for medical devices and tissue engineering scaffolds.

Basic Information

Product Name	Colominic Acid Sodium Salt
CAS No.	70431-34-4
Molecular Formula	(C11H17NNaO9)n
Molecular Weight	Variable (Polymer)
Synonyms	Poly(α-2,8-N-acetylneuraminic acid) sodium salt; Polysialic acid sodium salt; PolySia-Na; PSA sodium salt; Colominic acid, sodium derivative; α-2,8-Linked polysialic acid; (8S)-5-Acetamido-3,5-dideoxy-D-glycero-α-D-galacto-non-2-ulopyranosonic acid homopolymer sodium salt
EINECS	Contact for details

Quality Control

Our Colominic Acid Sodium Salt is produced and tested under stringent quality management systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, polymer length distribution, and biological activity where applicable. We support compliance with relevant research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This material is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Keep container tightly sealed in a dry and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR/NMR)	Conforms to structure
Assay (Sialic Acid Content)	≥ 95% (by colorimetric/HPLC)
Protein Content	≤ 1.0%
Nucleic Acid Content	≤ 0.5%
Endotoxin	< 10 EU/mg (for research-grade)
Molecular Size Distribution	Specified by DP (Degree of Polymerization) range (e.g., DP 10-50, 50-150)
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.