Description

Ethyl 5,6-Dichloro-3,4-Dihydro-2(1H)-Iminoquinazoline-3-Acetate Hydrobromide is a high-purity, advanced pharmaceutical intermediate with a CAS number of 70381-75-8. This compound is valued for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and cardiovascular disorders. It is essential for research institutions and pharmaceutical manufacturers engaged in drug discovery, process development, and the production of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of potent quinazoline-based drug candidates.
• Drug Discovery & Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new chemical entities.
• API Synthesis: Integral to the manufacturing process of final active pharmaceutical ingredients, especially for neurological and cardiovascular applications.
• Chemical Reference Standard: Serves as a high-purity standard for analytical method development and quality control in pharmaceutical laboratories.
• Process Chemistry: Employed in scale-up and optimization studies for efficient and cost-effective production routes.

Basic Information

Product Name	Ethyl 5,6-Dichloro-3,4-Dihydro-2(1H)-Iminoquinazoline-3-Acetate Hydrobromide
CAS No.	70381-75-8
Molecular Formula	C₁₂H₁₂BrCl₂N₃O₂
Molecular Weight	381.05 g/mol
Synonyms	5,6-Dichloro-3,4-dihydro-2(1H)-iminoquinazoline-3-acetic acid ethyl ester hydrobromide; Ethyl 5,6-dichloro-1,2,3,4-tetrahydro-2-iminoquinazoline-3-acetate hydrobromide; 70381-75-8; Quinazoline derivative intermediate; BRN 8732095
EINECS	Contact for details

Quality Control

Our Ethyl 5,6-Dichloro-3,4-Dihydro-2(1H)-Iminoquinazoline-3-Acetate Hydrobromide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.