Description

Methyl 2-Amino-3-Mercaptopropanoate Hydrochloride is a high-purity, protected cysteine derivative essential for advanced organic synthesis and pharmaceutical research. This compound is valued for its role as a key chiral building block in the development of complex molecules, particularly peptides and enzyme inhibitors. It is primarily sought by research institutions, pharmaceutical development labs, and fine chemical manufacturers engaged in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of cysteine-containing peptides, enzyme inhibitors, and other bioactive molecules.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) where a protected cysteine residue is required.
• Bioconjugation: Serves as a precursor for introducing thiol-reactive handles or for creating disulfide linkages in bioconjugates and antibody-drug conjugates (ADCs).
• Chemical Biology Research: Employed in the study of protein structure-function relationships and the development of activity-based probes.
• Asymmetric Synthesis: Utilized as a starting material or auxiliary in catalytic asymmetric transformations due to its chiral center.
• Reference Standard: Serves as an analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	Methyl 2-Amino-3-Mercaptopropanoate Hydrochloride
CAS No.	70361-61-4
Molecular Formula	C4H10ClNO2S
Molecular Weight	171.65 g/mol
Synonyms	L-Cysteine methyl ester hydrochloride; Methyl L-cysteinate hydrochloride; (R)-2-Amino-3-mercaptopropionic acid methyl ester hydrochloride; Cysteine methyl ester HCl; H-Cys-OMe·HCl; Methyl (2R)-2-amino-3-sulfanylpropanoate hydrochloride; 2-Amino-3-mercaptopropanoic acid methyl ester hydrochloride
EINECS	Contact for details

Quality Control

Our Methyl 2-Amino-3-Mercaptopropanoate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical research and development. A Certificate of Analysis (COA) detailing identity, purity (by HPLC), specific rotation, and related substances is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and easily oxidized nature. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.