Description

Avermectin A1A, 5-o-Demethyl-25-De(1-Methylpropyl)-22,23-Dihydro-25-(1-Methylethyl)- is a high-purity, semi-synthetic derivative of the naturally occurring avermectin family, valued for its potent biological activity and role as a key intermediate in advanced research and synthesis. This compound is critical for developing novel pharmaceutical agents and agrochemicals, offering researchers a precise tool for structure-activity relationship (SAR) studies and the creation of next-generation anthelmintic and insecticidal products. It is primarily sought by pharmaceutical R&D laboratories, agrochemical manufacturers, and academic research institutions focused on parasitology and medicinal chemistry.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel macrocyclic lactone derivatives with potential therapeutic applications.
• Agrochemical Research: Used in the development and study of new, more potent or selective insecticidal and acaricidal formulations.
• Veterinary Medicine Development: Serves as a key precursor in creating next-generation antiparasitic agents for animal health.
• Biochemical Research: Employed as a standard or probe in studies investigating ion channel (particularly glutamate-gated chloride channels) modulation and neuropharmacology.
• Structure-Activity Relationship (SAR) Studies: Essential for medicinal chemists to understand how structural modifications affect the biological potency and selectivity of avermectin analogs.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control of related compounds.

Basic Information

Product Name	Avermectin A1A, 5-o-Demethyl-25-De(1-Methylpropyl)-22,23-Dihydro-25-(1-Methylethyl)-
CAS No.	70209-81-3
Molecular Formula	C46H70O14
Molecular Weight	847.04 g/mol
Synonyms	5-O-Demethyl-25-de(1-methylpropyl)-22,23-dihydroavermectin A1a; 5-O-Desmethyl-25-de(1-methylpropyl)-22,23-dihydroavermectin A1a; 22,23-Dihydro-5-O-demethyl-25-de(1-methylpropyl)avermectin A1a; Avermectin A1a, 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro-; 5-O-Desmethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)avermectin A1a; LL-F28249-α; Nemadectin α; 5-O-Desmethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)-avermectin A1a
EINECS	Contact for details

Quality Control

Our Avermectin A1A derivative is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This compound is light-sensitive (store away from light) and hygroscopic (moisture-sensitive); prolonged exposure to air, light, or moisture should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.