Description

Mafenide Acetate is a synthetic sulfonamide antimicrobial agent with the CAS registry number 7761-27-5. It is valued for its broad-spectrum antibacterial activity, particularly against a wide range of gram-positive and gram-negative organisms. This compound is a critical active pharmaceutical ingredient (API) primarily utilized in the formulation of topical medications for the prevention and treatment of infections in severe burn wounds.

Application

• Topical Burn Creams: As the primary active ingredient in medicated creams (e.g., Sulfamylon®) for the prophylaxis and treatment of wound sepsis in second- and third-degree burns.
• Wound Care Formulations: Used in gels, ointments, and impregnated dressings to manage and prevent bacterial colonization in chronic wounds and skin grafts.
• Veterinary Medicine: Applied in topical preparations for treating bacterial skin infections and wounds in animals.
• Pharmaceutical Intermediates: Serves as a key starting material or intermediate in the synthesis of more complex sulfonamide-based drug molecules.
• Microbiological Research: Employed as a reference standard and selective agent in antimicrobial susceptibility testing and biochemical studies.

Basic Information

Product Name	Mafenide Acetate
CAS No.	7761-27-5
Molecular Formula	C7H10N2O2S • C2H4O2
Molecular Weight	246.27 g/mol
Synonyms	4-(Aminomethyl)benzenesulfonamide acetate; α-Amino-p-toluenesulfonamide acetate; p-(Aminomethyl)benzenesulfonamide monoacetate; Homosulfanilamide acetate; Sulfabenzamine acetate; Marfanil acetate; Ambamide acetate; Maphenide acetate; Marprontil acetate
EINECS	231-830-2

Quality Control

Our Mafenide Acetate is manufactured under strict quality management systems. It undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications, including identification, assay, impurity profiling, and residual solvent analysis. A Certificate of Analysis (COA) confirming compliance with relevant specifications, including in-house pharmacopeial standards, is provided with each batch.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Microbial Limits	Meets requirements for topical APIs

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.