Description

(R)-3,4-Dihydro-8-Methoxy-3,5-Dimethylisocoumarin is a high-purity chiral isocoumarin derivative, a versatile and valuable building block in advanced organic synthesis. Its defined stereochemistry and functionalized structure make it a critical intermediate for the development of enantiomerically pure pharmaceuticals and bioactive compounds. This product is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop novel active ingredients with specific stereochemical requirements.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of enantiomerically pure drug candidates, particularly for central nervous system (CNS) and anti-inflammatory agents.
• Agrochemical Synthesis: Used as a building block for developing novel, stereospecific pesticides and herbicides with enhanced activity and environmental profiles.
• Fine Chemical Production: Serves as a starting material for synthesizing complex natural product analogs, flavors, and fragrances requiring specific optical purity.
• Asymmetric Catalysis Research: Employed as a standard or ligand precursor in academic and industrial research to develop new chiral catalysts and methodologies.
• Biochemical Probe Development: Utilized in medicinal chemistry to create molecular probes for studying enzyme mechanisms and biological pathways.

Basic Information

Product Name	(R)-3,4-Dihydro-8-Methoxy-3,5-Dimethylisocoumarin
CAS No.	7736-76-7
Molecular Formula	C₁₂H₁₄O₃
Molecular Weight	206.24 g/mol
Synonyms	(R)-8-Methoxy-3,5-dimethyl-3,4-dihydroisocoumarin; (R)-3,4-Dihydro-8-methoxy-3,5-dimethyl-1H-2-benzopyran-1-one; (R)-3,5-Dimethyl-8-methoxy-3,4-dihydroisocoumarin; (R)-8-Methoxy-3,5-dimethyl-3,4-dihydro-2H-1-benzopyran-2-one; (R)-3,4-Dihydro-8-methoxy-3,5-dimethyl-2H-1-benzopyran-2-one; (R)-DMIC; (R)-Enantiomer of 3,4-Dihydro-8-methoxy-3,5-dimethylisocoumarin
EINECS	Contact for details

Quality Control

Our (R)-3,4-Dihydro-8-Methoxy-3,5-Dimethylisocoumarin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure it meets the high-purity standards required for advanced synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.