Description

n-o-Nitrophenylsulfenyl-L-Proline Di(Cyclohexyl)Ammonium Salt is a specialized chiral building block and protecting group reagent used in advanced organic synthesis. This compound is valued for its role in facilitating stereoselective peptide coupling and the controlled manipulation of amino acid derivatives. It is primarily utilized by research and development chemists in the pharmaceutical and biotechnology sectors for the synthesis of complex peptides, peptidomimetics, and other bioactive molecules requiring high enantiomeric purity.

Application

• Peptide Synthesis: Acts as a chiral auxiliary and protecting group for L-proline in solid-phase and solution-phase peptide synthesis.
• Pharmaceutical Intermediates: A key building block in the research and development of novel therapeutic peptides and protease inhibitors.
• Asymmetric Synthesis: Used to induce chirality and control stereochemistry in the synthesis of complex organic molecules.
• Bioconjugation Chemistry: Employed in the site-specific modification of peptides and proteins for drug delivery and diagnostic applications.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and medicinal chemistry laboratories.
• Production of Protected Amino Acids: For the preparation of enantiomerically pure, side-chain protected amino acid derivatives for further synthetic transformations.

Basic Information

Product Name	n-o-Nitrophenylsulfenyl-L-Proline Di(Cyclohexyl)Ammonium Salt
CAS No.	7675-53-8
Molecular Formula	C23H35N3O4S
Molecular Weight	449.61 g/mol
Synonyms	N-2-Nitrophenylsulfenyl-L-proline dicyclohexylammonium salt; (S)-1-((2-Nitrophenyl)thio)-1-oxopyrrolidine-2-carboxylic acid dicyclohexylammonium salt; Nps-L-Pro-OH·DCHA; 2-Nitrobenzenesulfenyl-L-proline dicyclohexylammonium salt; o-Nitrophenylsulfenyl-L-proline DCHA salt; NPS-Pro-OH DCHA salt; L-Proline, N-[(2-nitrophenyl)thio]-, compd. with N-cyclohexylcyclohexanamine (1:1)
EINECS	Contact for details

Quality Control

Our n-o-Nitrophenylsulfenyl-L-Proline Di(Cyclohexyl)Ammonium Salt is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for research and development applications. All materials are accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP standards for advanced pharmaceutical intermediate production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.