Description

5-Chloroquinazoline is a versatile and high-value halogenated heterocyclic building block essential for advanced organic synthesis. Its core value lies in its role as a key precursor for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and functional materials. This compound is critically needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with targeted biological or physical properties.

Application

• Pharmaceutical Intermediate: A crucial synthon for the synthesis of kinase inhibitors, anticancer agents, and other biologically active quinazoline derivatives.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and plant growth regulators that leverage the quinazoline scaffold.
• Material Science Precursor: Serves as a building block for organic light-emitting diodes (OLEDs), liquid crystals, and other advanced functional materials.
• Chemical Biology Probe: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and fragment-based drug discovery.
• Cross-Coupling Reactions: The chlorine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Buchwald-Hartwig amination.
• Nucleophilic Aromatic Substitution: Reacts readily with various nucleophiles (amines, alkoxides) to generate diverse 5-substituted quinazoline libraries.

Basic Information

Item	Details
Product Name	5-Chloroquinazoline
CAS No.	7556-90-3
Molecular Formula	C8H5ClN2
Molecular Weight	164.59 g/mol
Synonyms	5-Chloro-quinazoline; Quinazoline, 5-chloro-; 5-Chloroquinazoline; 5-Chloro-1,3-diazanaphthalene; 5-Chloro-benzo[d]pyrimidine; 5-Chloro-1,3-naphthyridine (less common); 7556-90-3; 5-Cl-Quinazoline
EINECS	Contact for details

Quality Control

Our 5-Chloroquinazoline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.