Description

n-Nitroso-L-Proline is a specialized nitrosated derivative of the amino acid L-proline. This compound is of significant interest in biochemical and toxicological research, particularly in the study of endogenous nitrosation and its biological implications. It serves as a critical reference standard and intermediate for researchers and manufacturers in the pharmaceutical and life science sectors. Its defined structure is essential for analytical method development and quality control in related chemical syntheses.

Application

• Biochemical Research: Used as a reference standard in studies of N-nitroso compound formation, metabolism, and carcinogenicity.
• Toxicology Studies: Employed as a model compound to investigate the mechanisms of endogenous nitrosation and DNA damage.
• Pharmaceutical Intermediate: Serves as a key synthetic building block for the development of novel therapeutic agents and probes.
• Analytical Chemistry: Acts as a high-purity calibration standard for HPLC, LC-MS, and other analytical techniques in method validation.
• Food Safety Research: Utilized in studies assessing the formation and risk of nitrosamines in food products and preservatives.
• Academic & Institutional Labs: Fundamental reagent for chemical education and advanced research in organic and medicinal chemistry.

Basic Information

Product Name	n-Nitroso-L-Proline
CAS No.	7519-36-0
Molecular Formula	C₅H₈N₂O₃
Molecular Weight	144.13 g/mol
Synonyms	L-Proline, N-nitroso-; N-Nitroso-L-proline; (S)-1-Nitrosopyrrolidine-2-carboxylic acid; Nitrosoproline; NSC 401005; 2-Pyrrolidinecarboxylic acid, N-nitroso-, (S)-; N-Nitroso-L-2-pyrrolidinecarboxylic acid; N-Nitroso-L-azetidine-2-carboxylic acid (related structure)
EINECS	Contact for details

Quality Control

Our n-Nitroso-L-Proline is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including identification (IR, NMR), purity assay (HPLC), and impurity profiling to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming batch-specific specifications and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.