Description

2-Chloro-1-Methylpyridinium p-Toluenesulfonate is a high-purity, versatile organic salt widely used as a powerful coupling agent and activating reagent in peptide synthesis and other organic transformations. Its primary value lies in its efficiency in facilitating amide bond formation, making it a critical component for researchers and manufacturers in advanced chemical synthesis. This compound is essential for pharmaceutical R&D, agrochemical production, and academic laboratories focused on developing novel bioactive molecules and polymers.

Application

• Peptide Synthesis: A key coupling reagent (often compared to PyBOP) for solid-phase and solution-phase peptide synthesis, enabling efficient amide bond formation.
• Pharmaceutical Intermediates: Used in the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs) requiring high-purity building blocks.
• Agrochemical Manufacturing: Employed in the production of advanced herbicides, fungicides, and insecticides that contain amide or peptide-like structures.
• Polymer Chemistry: Acts as a catalyst or activating agent in the synthesis of specialized polyamides and other condensation polymers.
• Bioconjugation: Facilitates the linking of peptides, proteins, or other biomolecules to carriers, dyes, or solid supports in biotech applications.
• Academic & Industrial Research: A valuable tool for methodological development in organic chemistry and for creating custom chemical libraries.

Basic Information

Product Name	2-Chloro-1-Methylpyridinium p-Toluenesulfonate
CAS No.	7403-46-5
Molecular Formula	C13H14ClNO3S
Molecular Weight	299.77 g/mol
Synonyms	1-Methyl-2-chloropyridinium p-toluenesulfonate; 2-Chloro-1-methylpyridinium tosylate; CMPT; Mukaiyama's Reagent (analog); Chloro-1-methylpyridinium Tosylate; 2-Chloro-N-methylpyridinium p-Toluenesulfonate; 1-Methyl-2-chloropyridinium Tosylate; 2-Chloro-1-methylpyridinium 4-methylbenzenesulfonate
EINECS	Contact for details

Quality Control

Our 2-Chloro-1-Methylpyridinium p-Toluenesulfonate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed after opening to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.