Description

4-Maleimidophenol is a high-purity, bifunctional organic compound featuring both a maleimide and a phenolic hydroxyl group. This unique structure makes it a versatile and critical building block for creating advanced materials with tailored properties. It is essential for researchers and manufacturers in the pharmaceutical, polymer science, and advanced materials sectors who require reliable, high-quality intermediates for cross-linking and conjugation applications.

Application

• Pharmaceutical Intermediate: Serves as a key linker in the synthesis of antibody-drug conjugates (ADCs) and other bioconjugates, enabling precise drug targeting.
• Polymer Modification: Used as a cross-linking agent and functional monomer to introduce reactive sites into polymers, enhancing thermal stability and mechanical properties.
• Surface Functionalization: Employed to modify material surfaces (e.g., nanoparticles, biosensors) with maleimide groups for subsequent biomolecule attachment.
• Adhesive & Coating Formulations: Acts as a curing agent and adhesion promoter in high-performance epoxy and polyimide systems.
• Research & Development: A valuable reagent in organic synthesis for constructing complex molecules and studying Michael addition reactions.
• Biotechnology: Facilitates the site-specific labeling and immobilization of proteins, peptides, and oligonucleotides.

Basic Information

Product Name	4-Maleimidophenol
CAS No.	7300-91-6
Molecular Formula	C10H7NO3
Molecular Weight	189.17 g/mol
Synonyms	4-Hydroxyphenylmaleimide; N-(4-Hydroxyphenyl)maleimide; p-Maleimidophenol; 1H-Pyrrole-2,5-dione, 1-(4-hydroxyphenyl)-; 4-HPM; Phenol, 4-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-; Maleimide, N-(p-hydroxyphenyl)-
EINECS	Contact for details

Quality Control

Our 4-Maleimidophenol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling, to meet exacting customer requirements. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	158 - 162 °C
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.