Description

5-Iodo-6-Nitro-1,3-Benzodioxole is a halogenated nitrobenzodioxole derivative, a specialized organic building block of significant interest in advanced chemical synthesis. Its unique structure, featuring both iodine and nitro substituents on the benzodioxole scaffold, makes it a valuable precursor for constructing complex molecules in pharmaceutical and agrochemical research. This compound is primarily sought by R&D chemists and process development scientists working in medicinal chemistry, where it serves as a key intermediate for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders or anti-infective agents.
• Agrochemical Research: Used in the development and optimization of new pesticides and herbicides, leveraging its reactive halogen and nitro groups for structural diversification.
• Material Science Precursor: Serves as a starting material for synthesizing specialized ligands, functionalized polymers, or organic electronic materials.
• Chemical Biology Probe Development: Employed in the creation of molecular probes and tags for studying biological systems and enzyme mechanisms.
• Cross-Coupling Reactions: The iodine substituent makes it a suitable substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create more complex biaryl or alkynyl structures.
• Nitro-Reduction Chemistry: The nitro group can be selectively reduced to an amine, enabling further functionalization and diversification of the molecular core.

Basic Information

Product Name	5-Iodo-6-Nitro-1,3-Benzodioxole
CAS No.	7106-74-3
Molecular Formula	C7H4INO4
Molecular Weight	292.02 g/mol
Synonyms	5-Iodo-6-nitrobenzo[d][1,3]dioxole; 6-Nitro-5-iodo-1,3-benzodioxole; 1,3-Benzodioxole, 5-iodo-6-nitro-; 5-Iodo-6-nitro-1,3-benzodioxol; 5-Iodo-6-nitrobenzo-1,3-dioxole
EINECS	Contact for details

Quality Control

Every batch of 5-Iodo-6-Nitro-1,3-Benzodioxole is manufactured and tested under a strict quality management system to ensure consistency and reliability for your research and development processes. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as purity (by HPLC), identity confirmation (by IR and NMR), and impurity profiles. Our quality commitment ensures the material meets the high standards required for advanced synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.