Description

5-(Trifluoromethyl)Isatoic Anhydride is a specialized fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the trifluoromethyl group, which imparts unique electronic and metabolic properties to target molecules, making it a critical intermediate for research and development. This compound is primarily sought by pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of drugs targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Research: Serves as a precursor for the development of specialty polymers, liquid crystals, and organic electronic materials that require fluorinated components.
• Dye and Pigment Industry: Acts as an intermediate in the synthesis of complex, high-performance dyes and pigments with improved lightfastness and color properties.
• Chemical Biology & Proteomics: Utilized as a reactive handle for bioconjugation and the development of chemical probes to study biological systems.

Basic Information

Product Name	5-(Trifluoromethyl)Isatoic Anhydride
CAS No.	781-94-2
Molecular Formula	C9H4F3NO3
Molecular Weight	231.13 g/mol
Synonyms	5-(Trifluoromethyl)-1H-benzo[d][1,3]oxazine-2,4-dione; 5-(Trifluoromethyl)-2H-3,1-benzoxazine-2,4(1H)-dione; 5-(Trifluoromethyl)anthranilic acid N-carboxyanhydride; Isatoic Anhydride, 5-(trifluoromethyl)-; 5-Trifluoromethylisatoic anhydride; 5-Trifluoromethyl-IA; 5-TFM-IA
EINECS	Contact for details

Quality Control

Our 5-(Trifluoromethyl)Isatoic Anhydride is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing including HPLC, NMR, and IR spectroscopy to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	178 - 182 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.