Description

1,3-Difluoropropan-2-Amine Hcl is a fluorinated amine hydrochloride salt, a versatile building block in advanced organic synthesis. Its value lies in the strategic incorporation of fluorine atoms and an amine functionality, which are critical for modulating the biological activity, metabolic stability, and physicochemical properties of target molecules. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoro motif can enhance lipophilicity and binding affinity.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral auxiliaries, ligands for asymmetric catalysis, and other specialty chemicals used in fine chemical synthesis.
• Fluorinated Molecule Library: An essential component for constructing diverse screening libraries in drug discovery to explore structure-activity relationships (SAR).
• Bioconjugation and Probe Development: Utilized in the synthesis of biochemical probes and labeling agents for diagnostic and research applications.
• Material Science Research: Investigated as a monomer or modifier in the synthesis of specialty polymers with unique surface properties or stability.

Basic Information

Product Name	1,3-Difluoropropan-2-Amine Hcl
CAS No.	760-25-8
Molecular Formula	C3H7F2N·HCl
Molecular Weight	139.55 g/mol
Synonyms	1,3-Difluoro-2-propanamine hydrochloride; 2-Amino-1,3-difluoropropane hydrochloride; 1,3-Difluoroisopropylamine HCl; 2-Propanamine, 1,3-difluoro-, hydrochloride; 1,3-Difluoro-2-aminopropane hydrochloride; 1,3-Difluoropropan-2-amine hydrochloride; 760-25-8; (1,3-Difluoropropan-2-yl)ammonium chloride
EINECS	Contact for details

Quality Control

Our 1,3-Difluoropropan-2-Amine Hcl is produced under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Recommended long-term storage at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.