Description

2-Chloro-3-Phenylquinazolin-4(3H)-One is a versatile and high-value heterocyclic building block with significant synthetic utility. This compound serves as a crucial intermediate in the development of advanced pharmaceutical agents and functional organic materials. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of biologically active quinazolinone derivatives, including potential kinase inhibitors and anticancer agents.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and plant growth regulators based on the quinazolinone scaffold.
• Organic Synthesis Building Block: The reactive chloro and carbonyl groups enable its use in cross-coupling reactions, nucleophilic substitutions, and cyclizations to create diverse heterocyclic systems.
• Material Science Research: Investigated as a component for organic light-emitting diodes (OLEDs) and other electronic materials due to its conjugated structure.
• Chemical Biology Probe Development: Utilized in medicinal chemistry for structure-activity relationship (SAR) studies and the creation of molecular probes.

Basic Information

Product Name	2-Chloro-3-Phenylquinazolin-4(3H)-One
CAS No.	727-62-8
Molecular Formula	C₁₄H₉ClN₂O
Molecular Weight	256.69 g/mol
Synonyms	2-Chloro-3-phenyl-4(3H)-quinazolinone; 3-Phenyl-2-chloro-4-quinazolinone; 2-Chloro-3-phenylquinazolin-4-one; 4(3H)-Quinazolinone, 2-chloro-3-phenyl-; 727-62-8; 2-Chloro-3-phenyl-4-quinazolinone; 2-Chloro-3-phenyl-3,4-dihydroquinazolin-4-one
EINECS	Contact for details

Quality Control

Our 2-Chloro-3-Phenylquinazolin-4(3H)-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.