Description

2,3,4,5,6-Pentafluorocinnamic Acid is a high-value fluorinated aromatic building block characterized by its cinnamic acid core with a fully fluorinated phenyl ring. This unique structure is critical for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules in advanced research and development. It is primarily sought after by pharmaceutical, agrochemical, and material science industries for the synthesis of novel active ingredients and specialty polymers. The compound's reactivity makes it a versatile intermediate for creating complex, fluorine-containing derivatives.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used in creating advanced, fluorinated pesticides and herbicides with enhanced efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorine-based compounds used in electronic display technologies.
• Polymer Modification: Incorporated into specialty polymers to improve chemical resistance, thermal stability, and surface properties.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Heck, and other palladium-catalyzed coupling reactions to create complex biaryl systems.
• Bioconjugation & Probe Development: Utilized in medicinal chemistry for attaching fluorinated tags to biomolecules for imaging and diagnostic applications.

Basic Information

Product Name	2,3,4,5,6-Pentafluorocinnamic Acid
CAS No.	719-60-8
Molecular Formula	C9H3F5O2
Molecular Weight	238.11 g/mol
Synonyms	(2,3,4,5,6-Pentafluorophenyl)acrylic Acid; Pentafluorocinnamic Acid; 3-(Perfluorophenyl)-2-propenoic Acid; 2-Propenoic acid, 3-(2,3,4,5,6-pentafluorophenyl)-; Perfluorocinnamic Acid; α,2,3,4,5,6-Hexafluorocinnamic Acid (deprecated); PFC Acid
EINECS	Contact for details

Quality Control

Our 2,3,4,5,6-Pentafluorocinnamic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content to ensure it meets stringent specifications. Certificates of Analysis (COA) documenting all critical quality attributes are provided with every shipment. We support compliance with global regulatory frameworks including REACH and can supply materials suitable for research and non-GMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to minimize exposure to atmospheric moisture. For long-term storage, consider the use of desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	158 - 162 °C
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.