Description

Bromo-(4-Fluoro-Phenyl)-Acetic Acid Ethyl Ester is a versatile fluorinated and brominated aromatic ester building block, prized for its dual reactive sites that enable sophisticated molecular construction. This compound is essential for the synthesis of complex active pharmaceutical ingredients (APIs) and advanced agrochemicals, where the introduction of fluorine and bromine atoms is critical for modulating biological activity and physicochemical properties. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with enhanced efficacy and stability.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of fluorinated drug candidates, particularly in CNS and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used to construct advanced herbicide and pesticide molecules where the fluorine moiety improves lipophilicity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated aromatic cores in electronic and display materials.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Heck, and Sonogashira couplings.
• Chemical Research & Development: Employed in academic and industrial labs for exploring new fluorination methodologies and creating specialized chemical libraries.
• Peptidomimetics & Bio-conjugates: The ester can be hydrolyzed to the corresponding acid for incorporation into peptide analogs or linker molecules.

Basic Information

Product Name	Bromo-(4-Fluoro-Phenyl)-Acetic Acid Ethyl Ester
CAS No.	712-52-7
Molecular Formula	C10H10BrFO2
Molecular Weight	261.09 g/mol
Synonyms	Ethyl 2-Bromo-2-(4-fluorophenyl)acetate; 2-Bromo-2-(4-fluorophenyl)acetic Acid Ethyl Ester; (4-Fluorophenyl)bromoacetic Acid Ethyl Ester; α-Bromo-4-fluorophenylacetic Acid Ethyl Ester; Ethyl α-Bromo-4-fluorophenylacetate; Bromo(4-fluorophenyl)ethanoic Acid Ethyl Ester; NSC 406906; 4-Fluoro-α-bromophenylacetic Acid Ethyl Ester
EINECS	Contact for details

Quality Control

Our production of Bromo-(4-Fluoro-Phenyl)-Acetic Acid Ethyl Ester adheres to stringent in-process controls to ensure batch-to-batch consistency and high chemical purity. Every lot is characterized by advanced analytical techniques including GC, HPLC, NMR, and IR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment, supporting cGMP and ISO 9001 compliant workflows for our global customer base.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.