Description

6-Chloroquinazoline is a versatile and high-value heterocyclic building block, essential for advanced organic synthesis. Its core value lies in its reactive chlorinated quinazoline scaffold, which serves as a key intermediate for constructing complex molecules with targeted biological activity. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, particularly in oncology and kinase inhibitor research.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of tyrosine kinase inhibitors (TKIs) and other small-molecule drug candidates.
• Agrochemical Research: Used in the development of new herbicides and fungicides, leveraging its heterocyclic structure for bioactivity.
• Material Science: Serves as a building block for creating functionalized organic materials and ligands for metal-organic frameworks (MOFs).
• Chemical Synthesis: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to introduce the quinazoline moiety into more complex architectures.
• Academic & R&D: A fundamental reagent for medicinal chemistry programs and structure-activity relationship (SAR) studies in university and industrial labs.

Basic Information

Product Name	6-Chloroquinazoline
CAS No.	700-78-7
Molecular Formula	C8H5ClN2
Molecular Weight	164.59 g/mol
Synonyms	6-Chloroquinazoline; Quinazoline, 6-chloro-; 6-Chloro-quinazoline; 6-Chloro-1,3-diazanaphthalene; 700-78-7; NSC 51128; CCRIS 6072; BRN 0119245
EINECS	Contact for details

Quality Control

Our 6-Chloroquinazoline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We adhere to cGMP principles for pharmaceutical-grade intermediates, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.