Description

Trifluoromethylmaleic Anhydride is a highly reactive fluorinated anhydride building block, essential for introducing the trifluoromethyl group into complex molecular architectures. Its unique structure offers significant advantages in modulating the electronic properties, metabolic stability, and lipophilicity of target compounds. This specialty chemical is primarily sought by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the CF₃ group enhances biological activity and environmental persistence.
• Material Science Monomer: Serves as a precursor for fluorinated polymers and coatings, imparting valuable properties like chemical resistance, low surface energy, and thermal stability.
• Ligand and Catalyst Development: Employed in the design of novel fluorinated ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Organic Synthesis Building Block: Utilized in Diels-Alder reactions and as a dienophile for constructing complex, fluorinated heterocyclic and carbocyclic systems.
• Fluorine-19 NMR Probe: Can be incorporated into molecules as a sensitive tag for NMR spectroscopy studies in chemical and biological research.

Basic Information

Product Name	Trifluoromethylmaleic Anhydride
CAS No.	700-27-6
Molecular Formula	C₅HF₃O₃
Molecular Weight	166.05 g/mol
Synonyms	2-(Trifluoromethyl)maleic Anhydride; 3-(Trifluoromethyl)furan-2,5-dione; 4-(Trifluoromethyl)-2,5-furandione; Maleic Anhydride, Trifluoromethyl-; TFMA; Trifluoromethylmaleic Anhydride; 2,5-Furandione, 3-(trifluoromethyl)-
EINECS	211-837-5

Quality Control

Our Trifluoromethylmaleic Anhydride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We adhere to relevant ISO standards and can support regulatory filings for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.