Description

4-Fluoro-3-(Trifluoromethyl)Cinnamic Acid is a high-value fluorinated cinnamic acid derivative characterized by its unique trifluoromethyl and fluoro substituents. This compound serves as a critical pharmaceutical intermediate and advanced building block in organic synthesis, enabling the introduction of lipophilic and electron-withdrawing groups. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, especially in kinase inhibitor and anti-inflammatory agent research.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides, leveraging the biological activity of the fluorinated aromatic system.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated organic semiconductors and liquid crystal compounds.
• Cross-Coupling Reactions: Acts as a substrate in Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Peptide Mimetics & Bio-conjugation: The carboxylic acid group allows for amide bond formation, useful in creating peptide analogs or linker molecules.
• Chemical Research & Development: A versatile reagent for academic and industrial research exploring new fluorinated chemical entities.

Basic Information

Product Name	4-Fluoro-3-(Trifluoromethyl)Cinnamic Acid
CAS No.	695187-00-9
Molecular Formula	C10H6F4O2
Molecular Weight	234.15 g/mol
Synonyms	(E)-3-[4-Fluoro-3-(trifluoromethyl)phenyl]acrylic acid; 3-(4-Fluoro-3-(trifluoromethyl)phenyl)-2-propenoic acid; 4-Fluoro-α,α,α-trifluoro-m-cinnamic acid; trans-4-Fluoro-3-trifluoromethylcinnamic acid; 4-Fluoro-3-trifluoromethylcinnamic acid; FTCA; 4F-3TFMCA
EINECS	Contact for details

Quality Control

Our 4-Fluoro-3-(Trifluoromethyl)Cinnamic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality system is designed to meet the stringent requirements of cGMP for advanced intermediates and supports compliance with global regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.