Description

2,4-Bis(Trifluoromethyl)Imidazo[1,2-A][1,8]Naphthyridine-8-Carbohydrazide is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure and trifluoromethyl functional groups. This compound matters for its critical role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting complex disease pathways. Industrial and research chemists in the pharmaceutical, agrochemical, and advanced materials sectors need this specialized chemical for developing next-generation products with enhanced efficacy and stability.

Application

• Pharmaceutical Intermediate: A crucial precursor in the research and development of new drug candidates, especially in oncology and antiviral therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced, high-performance pesticides and herbicides where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Research: Serves as a specialized monomer or additive in the development of novel organic electronic materials, such as OLEDs or conductive polymers.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and cellular processes.
• Organic Synthesis Building Block: Provides a versatile scaffold for medicinal chemistry, enabling the exploration of new chemical space in lead optimization.
• Fluorinated Compound Library: A key component for constructing libraries of fluorinated compounds for high-throughput screening in drug discovery.

Basic Information

Product Name	2,4-Bis(Trifluoromethyl)Imidazo[1,2-A][1,8]Naphthyridine-8-Carbohydrazide
CAS No.	691868-81-2
Molecular Formula	C₁₄H₆F₆N₆O
Molecular Weight	388.23 g/mol
Synonyms	8-Hydrazinylcarbonyl-2,4-bis(trifluoromethyl)imidazo[1,2-a][1,8]naphthyridine; 2,4-Bis(trifluoromethyl)imidazo[1,2-a][1,8]naphthyridine-8-carboxylic acid hydrazide; Imidazo[1,2-a][1,8]naphthyridine-8-carbohydrazide, 2,4-bis(trifluoromethyl)-; 691868-81-2; BTIN-8-CH; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of 2,4-Bis(Trifluoromethyl)Imidazo[1,2-A][1,8]Naphthyridine-8-Carbohydrazide adheres to stringent quality management protocols to ensure batch-to-batch consistency and purity for critical R&D and scale-up processes. All materials undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.