Description

1-Oxaspiro[2.4]Hept-6-En-4-Ol, 2,7-Diethynyl-, (2S,3S,4R)- (9Ci) is a high-value, stereochemically defined spirocyclic building block containing both hydroxyl and ethynyl functional groups. This compound matters as a sophisticated chiral intermediate, enabling the synthesis of complex molecules with precise three-dimensional architecture for advanced research and development. It is primarily needed by pharmaceutical and agrochemical R&D teams, as well as academic researchers, for applications in medicinal chemistry, asymmetric synthesis, and the development of novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery.
• Agrochemical Synthesis: Used in the creation of novel, stereospecific pesticides and herbicides where specific spatial orientation is critical for biological activity.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for synthesizing novel chiral ligands and organocatalysts used in enantioselective transformations.
• Material Science Research: Investigated as a monomer or cross-linking agent for creating advanced polymers with unique thermal or mechanical properties due to its rigid spiro structure and reactive alkynes.
• Chemical Biology Probe Development: Utilized in click chemistry applications via its ethynyl groups for labeling and studying biological systems.
• Academic & Institutional Research: Employed in synthetic organic chemistry studies focused on novel ring systems and stereocontrolled reactions.

Basic Information

Product Name	1-Oxaspiro[2.4]Hept-6-En-4-Ol, 2,7-Diethynyl-, (2S,3S,4R)- (9Ci)
CAS No.	691012-69-8
Molecular Formula	C11H10O2
Molecular Weight	174.20 g/mol
Synonyms	(2S,3S,4R)-2,7-Diethynyl-1-oxaspiro[2.4]hept-6-en-4-ol; (2S,3S,4R)-2,7-Diethynyl-1-oxaspiro[2.4]hept-6-en-4-ol (9CI); 1-Oxaspiro[2.4]hept-6-ene-4-ol, 2,7-diethynyl-, (2S,3S,4R)-; 691012-69-8; (2S,3S,4R)-2,7-Diethynyl-1-oxaspiro[2.4]hept-6-en-4-ol; Spirocyclic oxa-alkyne alcohol; Chiral spiro ether alkyne.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC for chiral purity and assay, NMR, and MS, to ensure identity, stereochemical integrity, and chemical purity meet exacting customer specifications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound may be sensitive to moisture and oxidation; for long-term storage, consider storage under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.