Description

3-Aminomethyl-2-Boc-3,4-Dihydro-1H-Isoquinoline CAS NO 690244-91-8 is a protected amine derivative of the isoquinoline scaffold, serving as a crucial advanced pharmaceutical intermediate (API) and building block in organic synthesis. Its value lies in providing a versatile, reactive amino group protected by the acid-labile Boc (tert-butoxycarbonyl) group, enabling selective deprotection and further functionalization under mild conditions. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel drug candidates and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and cardiovascular drug discovery.
• Organic Synthesis Reagent: Used in the construction of complex nitrogen-containing heterocycles and natural product analogs.
• Agrochemical Research: Intermediate in the development of new pesticides and herbicides with specific biological activity.
• Peptidomimetics & Medicinal Chemistry: Serves as a constrained scaffold for designing peptide mimics and small molecule libraries for high-throughput screening.
• Chemical Biology Probes: Utilized in the synthesis of labeled compounds and probes for studying biological pathways and enzyme function.
• Catalyst & Ligand Development: Potential precursor for chiral ligands and organocatalysts used in asymmetric synthesis.

Basic Information

Product Name	3-Aminomethyl-2-Boc-3,4-Dihydro-1H-Isoquinoline
CAS No.	690244-91-8
Molecular Formula	C16H22N2O2
Molecular Weight	274.36 g/mol
Synonyms	2-(tert-Butoxycarbonyl)-3-(aminomethyl)-3,4-dihydro-1H-isoquinoline; 3-(Aminomethyl)-2-[(tert-butoxycarbonyl)amino]-3,4-dihydroisoquinoline; tert-Butyl N-[3-(aminomethyl)-3,4-dihydro-1H-isoquinolin-2-yl]carbamate; 2-Boc-3-aminomethyl-1,2,3,4-tetrahydroisoquinoline; 3-Aminomethyl-2-Boc-1,2,3,4-tetrahydroisoquinoline; 2-Boc-3-ATIQ; Boc-protected 3-aminomethyl-TIQ
EINECS	Contact for details

Quality Control

Our 3-Aminomethyl-2-Boc-3,4-Dihydro-1H-Isoquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for critical research and production applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions (e.g., nitrogen or argon atmosphere) for long-term storage to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.