Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-7-(4-Ethyl-1-Piperazinyl)-6-Fluoro-1,4-Dihydro-4-Oxo-, Phenylmethyl Ester is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is a key synthetic precursor in the development of novel fluoroquinolone antibiotics, offering critical structural complexity for targeted therapeutic activity. It is primarily required by pharmaceutical R&D laboratories, process development chemists, and manufacturers engaged in the synthesis of next-generation antibacterial agents.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of proprietary fluoroquinolone antibiotic candidates.
• Active Pharmaceutical Ingredient (API) Development: Used in research and process chemistry for developing new antibacterial agents targeting resistant pathogens.
• Chemical Reference Standard: Serves as a high-purity standard for analytical method development, validation, and quality control in pharmaceutical manufacturing.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies to optimize the potency and safety profile of quinolone-based therapeutics.
• Process Scale-Up: Supplied for pilot plant and commercial-scale production campaigns under cGMP guidelines.
• Contract Manufacturing: Sourced by CDMOs (Contract Development and Manufacturing Organizations) for client-specific API synthesis projects.

Basic Information

Item	Detail
Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-7-(4-Ethyl-1-Piperazinyl)-6-Fluoro-1,4-Dihydro-4-Oxo-, Phenylmethyl Ester
CAS No.	686773-92-2
Molecular Formula	C26H28FN3O3
Molecular Weight	449.52 g/mol
Synonyms	Benzyl 1-Cyclopropyl-7-(4-ethylpiperazin-1-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate; 1-Cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid Phenylmethyl Ester; Garenoxacin Benzyl Ester; Garenoxacin Intermediate; BMS-284756 Benzyl Ester; T-3811 Benzyl Ester
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality systems suitable for pharmaceutical applications. Every batch is characterized and tested using validated analytical methods, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing all critical quality attributes. We support development under cGMP guidelines and can tailor specifications to meet the specific requirements of your regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.