Description

6-((Trimethylsilyl)Ethynyl)Quinoline is a specialized organosilicon building block featuring a quinoline core functionalized with a trimethylsilyl-protected ethynyl group. This compound is of significant value in advanced organic synthesis, particularly in cross-coupling reactions and as a precursor for more complex heterocyclic systems. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the construction of complex drug candidates, especially those containing quinoline or acetylenic pharmacophores.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides that require the quinoline scaffold for biological activity.
• Material Science Precursor: Acts as a monomer or building block for the development of organic semiconductors, luminescent materials, and metal-organic frameworks (MOFs).
• Cross-Coupling Reactions: The protected alkyne group is a versatile handle for Sonogashira, Glaser, and other palladium-catalyzed coupling reactions to create conjugated systems.
• Ligand Synthesis: Utilized in the preparation of novel nitrogen-containing ligands for catalysis and coordination chemistry.
• Chemical Biology Probes: Employed in the synthesis of fluorescent or affinity tags for studying biological processes.

Basic Information

Product Name	6-((Trimethylsilyl)Ethynyl)Quinoline
CAS No.	683774-32-5
Molecular Formula	C₁₄H₁₇NSi
Molecular Weight	227.38 g/mol
Synonyms	6-((Trimethylsilyl)ethynyl)quinoline; 6-[(Trimethylsilyl)ethynyl]quinoline; Quinoline, 6-[(trimethylsilyl)ethynyl]-; 6-(Trimethylsilylethynyl)quinoline; 6-(2-Trimethylsilylethynyl)quinoline; 6-Ethynylquinoline trimethylsilyl ether; TMS-ethynylquinoline
EINECS	Contact for details

Quality Control

Our 6-((Trimethylsilyl)Ethynyl)Quinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere such as nitrogen or argon to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.