Description

2,3-Difluoro-4-Methylcinnamic Acid is a fluorinated cinnamic acid derivative, a high-value organic building block prized for its unique molecular architecture. This compound matters for its role as a critical intermediate in the synthesis of advanced pharmaceutical agents and functional materials, where the fluorine atoms and cinnamic acid backbone impart specific biological activity and physicochemical properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology, where the difluoro-methyl motif is crucial for metabolic stability and binding affinity.
• Agrochemical Synthesis: Used in developing new-generation herbicides, fungicides, and plant growth regulators, leveraging the fluorine atoms to enhance lipophilicity and systemic activity.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated organic semiconductors and liquid crystal compounds used in display technologies, benefiting from the electronic effects of fluorine.
• Chemical Biology Probes: Employed in the design of fluorescent tags and molecular probes for studying enzyme activity and cellular processes due to its modifiable carboxylic acid group.
• Polymer Modification: Acts as a monomer or cross-linking agent for introducing fluorine into polymer chains to improve chemical resistance, thermal stability, and surface properties.
• Academic & Contract Research: Essential for medicinal chemistry programs and structure-activity relationship (SAR) studies in university and CRO (Contract Research Organization) laboratories.

Basic Information

Item	Detail
Product Name	2,3-Difluoro-4-Methylcinnamic Acid
CAS No.	682804-96-2
Molecular Formula	C₁₀H₈F₂O₂
Molecular Weight	198.17 g/mol
Synonyms	(2E)-3-(2,3-Difluoro-4-methylphenyl)prop-2-enoic acid; 2,3-Difluoro-4-methyl-trans-cinnamic acid; 3-(2,3-Difluoro-4-methylphenyl)acrylic acid; 2,3-Difluoro-4-methylcinnamate; 682804-96-2 (CAS Index Name); DFMCA; 4-Methyl-2,3-difluorocinnamic acid
EINECS	Contact for details

Quality Control

Our 2,3-Difluoro-4-Methylcinnamic Acid is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the high standards required for research and production. Certificates of Analysis (COA) with complete batch data are provided to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.