Description

Cyclopropanamine, 2-Bromo-3-Methyl-, (1R,2S,3S)-Rel- (9Ci) is a high-purity, stereochemically defined chiral building block of significant interest in advanced organic synthesis. This compound matters because its unique cyclopropane ring system, combined with bromine and amine functional groups, provides a versatile scaffold for constructing complex molecular architectures with precise three-dimensional control. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications such as medicinal chemistry, asymmetric synthesis, and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in programs targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the discovery and process development of new herbicides, fungicides, and insecticides, where the cyclopropane motif can confer specific biological activity and stability.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for the synthesis of chiral ligands and organocatalysts used in enantioselective transformations.
• Medicinal Chemistry & SAR Studies: Employed to explore structure-activity relationships (SAR) by introducing a constrained, three-membered ring into lead compounds to modulate conformation, potency, and metabolic profile.
• Chemical Biology Probe Development: Utilized as a reactive handle for the synthesis of molecular probes to study enzyme mechanisms or protein-ligand interactions.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic synthesis, including ring-opening and cross-coupling reactions.

Basic Information

Product Name	Cyclopropanamine, 2-Bromo-3-Methyl-, (1R,2S,3S)-Rel- (9Ci)
CAS No.	681536-39-0
Molecular Formula	C4H8BrN
Molecular Weight	150.02 g/mol
Synonyms	(1R,2S,3S)-rel-2-Bromo-3-methylcyclopropanamine; rel-(1R,2S,3S)-2-Bromo-3-methylcyclopropanamine; 2-Bromo-3-methylcyclopropanamine (rel-(1R,2S,3S)-); (1R,2S,3S)-2-Bromo-3-methylcyclopropanamine (relative); Cyclopropanamine, 2-bromo-3-methyl-, (1R,2S,3S)-rel-; 2-Bromo-3-methyl-1-aminocyclopropane (relative configuration)
EINECS	Contact for details

Quality Control

Our Cyclopropanamine, 2-Bromo-3-Methyl-, (1R,2S,3S)-Rel- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric/excess determination, NMR for structural confirmation, and purity assessment to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided for every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under an inert atmosphere when appropriate to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de (diastereomeric excess)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.