Description

(S)-α-(2-Naphthalenylmethyl)-Proline-Hcl is a high-purity, non-natural amino acid derivative used as a critical chiral building block in advanced organic synthesis. This compound matters for its role in constructing complex molecular architectures with precise stereochemistry, essential for developing active pharmaceutical ingredients (APIs) and other fine chemicals. It is needed by research scientists and process chemists in the pharmaceutical, agrochemical, and biotechnology industries for applications ranging from drug discovery to process development and scale-up.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of protease inhibitors, enzyme inhibitors, and other bioactive molecules.
• Peptidomimetic Research: Used to introduce constrained proline analogs and bulky hydrophobic side chains into peptide backbones to enhance metabolic stability and binding affinity.
• Asymmetric Catalysis: Serves as a precursor for chiral ligands or organocatalysts used in stereoselective transformations.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes to study enzyme function and protein-protein interactions.
• Agrochemical Development: Utilized as a building block for creating novel chiral active ingredients with improved efficacy and environmental profiles.
• Academic & Contract Research: A valuable reagent for methodological development in organic chemistry and medicinal chemistry research programs.

Basic Information

Product Name	(S)-α-(2-Naphthalenylmethyl)-Proline Hydrochloride
CAS No.	679796-43-1
Molecular Formula	C₁₇H₁₉NO₂·HCl
Molecular Weight	305.80 g/mol
Synonyms	(S)-2-(Naphthalen-2-ylmethyl)pyrrolidine-2-carboxylic acid hydrochloride; (2S)-2-[(Naphthalen-2-yl)methyl]proline hydrochloride; L-Proline, 2-[(2-naphthalenyl)methyl]-, hydrochloride (1:1); (S)-α-(2-Naphthylmethyl)proline hydrochloride; (S)-2-((2-Naphthyl)methyl)proline HCl; (S)-Naphthalen-2-ylmethyl-proline HCl; Proline derivative 679796-43-1
EINECS	Contact for details

Quality Control

Our (S)-α-(2-Naphthalenylmethyl)-Proline-Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for research and development use. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.