Description

1-Allyl-Pyrrolidine-2-Carboxylic Acid Hydrochloride is a high-purity, non-natural amino acid derivative in its hydrochloride salt form, offering enhanced stability and handling properties. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, enabling the construction of complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), peptidomimetics, and specialized fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in neurological and metabolic disorder therapies.
• Peptidomimetic Chemistry: Used to introduce constrained proline-like structures into peptide backbones to enhance metabolic stability and biological activity.
• Ligand Synthesis for Catalysis: Serves as a precursor for synthesizing novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Academic & Industrial Research: A valuable reagent for methodological studies in organic chemistry and for exploring new reaction pathways.
• Chemical Biology Probes: Incorporated into molecular probes to study enzyme function and protein-protein interactions.

Basic Information

Product Name	1-Allyl-Pyrrolidine-2-Carboxylic Acid Hydrochloride
CAS No.	678988-13-1
Molecular Formula	C8H13NO2 • HCl
Molecular Weight	191.65 g/mol (Free base: 155.19 g/mol)
Synonyms	1-Allyl-L-proline hydrochloride; (S)-1-Allylpyrrolidine-2-carboxylic acid hydrochloride; L-Proline, 1-allyl-, hydrochloride; 1-Allyl-2-pyrrolidinecarboxylic acid hydrochloride; Allylproline hydrochloride; 1-N-Allylproline HCl; (2S)-1-(Prop-2-en-1-yl)pyrrolidine-2-carboxylic acid hydrochloride
EINECS	Contact for details

Quality Control

Every batch of 1-Allyl-Pyrrolidine-2-Carboxylic Acid Hydrochloride is manufactured under strict quality management systems. We provide comprehensive analytical documentation to ensure traceability and compliance with your research or cGMP starting material requirements. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing identity, purity, and chiral integrity are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.