Description

(1S,2S,3R,4R)-(+)-3-Aminobicyclo[2.2.1]Hept-5-Ene-2-Carboxylic Acid Hydrochloride is a high-purity, chiral bicyclic amino acid derivative, serving as a critical building block in advanced organic synthesis. Its rigid, constrained structure and defined stereochemistry make it invaluable for constructing complex molecular architectures with precise spatial orientation. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and chiral catalysts.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, especially in neurology and metabolic disease therapies.
• Asymmetric Synthesis: Used as a precursor or auxiliary in catalytic asymmetric reactions to induce high enantioselectivity.
• Peptidomimetics & Conformationally Restricted Peptides: Incorporated into peptide chains to impose specific backbone conformations, enhancing biological activity and metabolic stability.
• Ligand & Catalyst Development: Serves as a core structure for designing novel chiral ligands and organocatalysts.
• Agrochemical Research: Employed in the synthesis of chiral active ingredients for crop protection products.
• Academic & R&D Laboratories: A valuable tool for methodological studies in organic chemistry and medicinal chemistry.

Basic Information

Product Name	(1S,2S,3R,4R)-(+)-3-Aminobicyclo[2.2.1]Hept-5-Ene-2-Carboxylic Acid Hydrochloride
CAS No.	677757-33-4
Molecular Formula	C8H12ClNO2
Molecular Weight	189.64 g/mol
Synonyms	(1S,2S,3R,4R)-3-Amino-2-carboxybicyclo[2.2.1]hept-5-ene hydrochloride; (1S,2S,3R,4R)-(+)-3-Aminonorborn-5-ene-2-carboxylic acid hydrochloride; endo-(1S,2S,3R,4R)-3-Aminobicyclo[2.2.1]hept-5-ene-2-carboxylic acid HCl; Bicyclo[2.2.1]hept-5-ene-2-carboxylic acid, 3-amino-, hydrochloride, (1S,2S,3R,4R)-; Chiral NBOC-HCl derivative
EINECS	Contact for details

Quality Control

Every batch of our (1S,2S,3R,4R)-(+)-3-Aminobicyclo[2.2.1]Hept-5-Ene-2-Carboxylic Acid Hydrochloride is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and enantiomeric excess meet the exacting standards required for research and cGMP starting material applications. A detailed Certificate of Analysis (COA) with HPLC/Chiral HPLC, NMR, and MS data is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.