Description

Tetanus Toxin CAS NO 676570-37-9 is a potent neurotoxin produced by the bacterium *Clostridium tetani*. This highly specific biological agent is critical for advanced neurological research and the development of vaccines and antitoxins. It is primarily utilized by research institutions, pharmaceutical developers, and diagnostic manufacturers focused on neuroscience, immunology, and public health.

Application

• Neuroscience Research: A key tool for studying synaptic transmission, neuronal inhibition, and the mechanisms of neurotoxicity.
• Vaccine Development & Potency Testing: Essential as an antigen in the production and quality control (QC) testing of tetanus vaccines.
• Antitoxin & Therapeutic Antibody Production: Used to generate and standardize tetanus immune globulins and monoclonal antibodies.
• Diagnostic Reagent Manufacturing: Serves as a critical component in immunoassays and diagnostic kits for tetanus antibody detection.
• Pharmacological Studies: Employed in research investigating neuromuscular blockers and potential therapeutic applications of toxin fragments.
• Cell Biology & Intracellular Trafficking: Used as a probe to study neuronal uptake, retrograde transport, and intracellular protein targeting.

Basic Information

Item	Detail
Product Name	Tetanus Toxin
CAS No.	676570-37-9
Molecular Formula	Contact for details
Molecular Weight	~150 kDa (Protein)
Synonyms	Tetanus Toxin; Tetanospasmin; TeNT; Clostridium tetani Toxin; Tetanus Neurotoxin; TeTx; TT; Tetanus Exotoxin
EINECS	Contact for details

Quality Control

Our Tetanus Toxin is produced and handled under stringent quality systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, potency, and safety for research use. A detailed Certificate of Analysis (COA) documenting purity (by HPLC/SDS-PAGE), protein concentration, specific activity (LD50), and sterility/endotoxin levels is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at -20°C or below. Avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive) and should be handled in a controlled, dry environment. Always follow safe laboratory practices for handling potent biological toxins.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear solution
Identification (Immunological)	Conforms
Purity (SDS-PAGE)	> 95%
Protein Content	As per COA
Specific Activity (Potency)	> 2 x 107 LD50/mg
Endotoxin Level	< 10 EU/mg
Sterility (Membrane Filtration)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.