Description

tert-Butyl 8-Hydroxy-3,4-Dihydroquinoline-1(2H)-Carboxylate is a high-purity, protected heterocyclic building block of significant value in advanced organic synthesis. This compound matters because it serves as a critical intermediate for constructing complex molecular architectures, particularly in pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel quinoline-based drug candidates, including potential kinase inhibitors and central nervous system (CNS) active compounds.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where the dihydroquinoline scaffold imparts specific biological activity.
• Material Science Precursor: Serves as a building block for creating specialized organic ligands, dyes, and photoactive materials.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological studies and the exploration of new heterocyclic chemistry.
• Process Chemistry Development: Utilized for scaling up synthetic routes to target molecules, where the tert-butyloxycarbonyl (Boc) protecting group offers strategic advantages.

Basic Information

Product Name	tert-Butyl 8-Hydroxy-3,4-Dihydroquinoline-1(2H)-Carboxylate
CAS No.	676255-10-0
Molecular Formula	C14H17NO3
Molecular Weight	247.29 g/mol
Synonyms	1-Boc-8-Hydroxy-1,2,3,4-tetrahydroquinoline; 8-Hydroxy-1,2,3,4-tetrahydroquinoline-1-carboxylic acid tert-butyl ester; tert-Butyl 8-hydroxy-1,2,3,4-tetrahydroquinoline-1-carboxylate; 1,2,3,4-Tetrahydro-8-hydroxyquinoline-1-carboxylic acid tert-butyl ester; 8-Hydroxy-1,2,3,4-tetrahydroquinoline N-Boc derivative; Boc-8-OH-THQ; 676255-10-0
EINECS	Contact for details

Quality Control

Our tert-Butyl 8-Hydroxy-3,4-Dihydroquinoline-1(2H)-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with full analytical data are provided to guarantee traceability and batch-to-batch consistency, meeting the stringent requirements of research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.